Journal: Asian Pacific Journal of Cancer Prevention : APJCP
Article Title: A Novel Class of Functionalized Synthetic Fluoroquinolones with Dual Antiproliferative - Antimicrobial Capacities
doi: 10.31557/APJCP.2021.22.4.1075
Figure Lengend Snippet: Cytotoxicity in vitro (as of %Control) IC 50 Value in µM (µg/mL) in a Diverse Panel of Cancer Cell Lines vs. cisplatin . Selectivity index (SI) of the tested compounds against PDL Fibroblasts vs. cisplatin’s
Article Snippet: A375.S2 cell line ATCC ® CRL-1872TM, A549 cell line ATCC ® CCL-185TM, HELA cell line ATCC® CCL-2TM were cultured in Dulbecco’s modified eagle’s medium (DMEM). (DMEM) containing foetal bovine serum (FBS) (Bio Whittaker, Verviers, Belgium), 4-(2-hydroxyethyl)-1-piperazine ethane sulfonic acid (HEPES) Buffer, L-glutamine, gentamicin, penicillin, and streptomycin sulphate (Sigma, St. Luis, MO, USA), trypsin, trypan blue, Ciprofloxacin HCl from Aarti drugs Ltd/India, was a kind gift from Pharma International Company- Amman; Fluconazole from Neopharma, United Arab Emirates, a kind gift from Pharmaceutical Research Unit, Amman; Trypon soya agar (TSA), trypon soya broth (TSB), sabouraud dextrose agar (SDA) were obtained from Liofilchem (Italy) or Oxoid LTD (Basingstoke, England), they were reconstituted and sterilized by autoclave at 121 ° C for 15 min. General procedure to prepare target compounds , , The spectral data of all compounds were reported elsewhere (Arabiyat et al. 2016a,b; 2017;Alabsi et al. 2018; Jumah 2018; AlShahrabi et al., 2020).
Techniques: In Vitro, Control